#Majorhistocompatibilitycomplex #MHCclass1 #MHCclass2
There are two major classes of MHC molecules, both of which consist of an a and a b chain, but from different sources. MHC class I molecules (MHC I) consist of one membrane-spanning a chain (heavy chain) produced by MHC genes, and one b chain (light chain or b2-microglobulin) produced by the b2-microglobulin gene. MHC class II molecules (MHC II) consist of two membrane-spanning chains, a and b, of similar size and both produced by MHC genes. In each case, the MHC molecule has a groove that binds a peptide, which it can then present at the cell surface to a T cell to elicit an immune response, because T cells only recognise antigens as complexes with MHC molecules. The two classes of MHC proteins differ not only in their structure, but more importantly in their functional roles within the immune system: the two types of MHC molecules are specialised to present different types of antigens, thereby eliciting different responses.

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