Pleural friction rub is an abnormal lung sound which is caused by inflammation of the pleural layer of the lungs rubbing together. Pleural friction rub is heard on inspiration and expiration and sounds like a low-pitch harsh/grating noise. Pleural friction rubs may sound similar to pericardial friction rubs. However, to tell the difference when listening to a patient, have the patient hold their breath and if the sound disappears it is not a pleural friction rub but a possible pericardial friction rub.

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