Ain't nothin' gonna break my stride, nobody gonna slow me down, oh no,
I got to keep blood moving! Today's #ClinicalCuts is all about the renin-angiotensin-aldosterone system, which helps keep blood movin'.

The main job of the cardiovascular system is to keep the blood moving, and to help facilitate that, blood pressure and other critical functions are kept under tight control. A major way the body does that is through a set of hormones that make up the renin-angiotensin-aldosterone system.

Renin is an enzyme that gets into the plasma and looks for its primary substrate, angiotensinogen.

Angiotensinogen is a large protein made up of over 400 amino acids that’s produced by the liver and is always hanging out in the blood.

When they meet up, renin cleaves off a huge chunk of the angiotensinogen protein, leaving behind a tiny fragment called Angiotensin I that’s just 10 amino acids long – a bit like a tiny pearl found within a giant oyster!

To learn more about the intricacies of the renin-angiotensin-aldosterone system, head over to Osmosis for the full video and explanation: https://osms.it/cc-renin-angio-aldo-sys-yt

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