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Chapters

0:00 Introduction
0:43 Causes of bladder infection
1:16 Symptoms of bladder infection
1:40 Diagnosis of bladder infection
2:02 Treatment for bladder infection
2:29 Prevention of bladder infection


bladder infection (cystitis) and when it affects the upper urinary tract it is known as a kidney infection (pyelonephritis).[10] Symptoms from a lower urinary tract infection include pain with urination, frequent urination, and feeling the need to urinate despite having an empty bladder.[1] Symptoms of a kidney infection include fever and flank pain usually in addition to the symptoms of a lower UTI.[10] Rarely the urine may appear bloody.[7] In the very old and the very young, symptoms may be vague or non-specific.[1][11]

The most common cause of infection is Escherichia coli, though other bacteria or fungi may sometimes be the cause.[2] Risk factors include female anatomy, sexual intercourse, diabetes, obesity, and family history.[2] Although sexual intercourse is a risk factor, UTIs are not classified as sexually transmitted infections (STIs).[12] Kidney infection, if it occurs, usually follows a bladder infection but may also result from a blood-borne infection.[13] Diagnosis in young healthy women can be based on symptoms alone.[4] In those with vague symptoms, diagnosis can be difficult because bacteria may be present without there being an infection.[14] In complicated cases or if treatment fails, a urine culture may be useful.[3]

In uncomplicated cases, UTIs are treated with a short course of antibiotics such as nitrofurantoin or trimethoprim/sulfamethoxazole.[7] Resistance to many of the antibiotics used to treat this condition is increasing.[1] In complicated cases, a longer course or intravenous antibiotics may be needed.[7] If symptoms do not improve in two or three days, further diagnostic testing may be needed.[3] Phenazopyridine may help with symptoms.[1] In those who have bacteria or white blood cells in their urine but have no symptoms, antibiotics are generally not needed,[15] although during pregnancy is an exception.[16] In those with frequent infections, a short course of antibiotics may be taken as soon as symptoms begin or long-term antibiotics may be used as a preventive measure.[17]

About 150 million people develop a urinary tract infection in a given year.[2] They are more common in women than men, but similar between anatomies while carrying indwelling catheters.[7][18] In women, they are the most common form of bacterial infection.[19] Up to 10% of women have a urinary tract infection in a given year, and half of women have at least one infection at some point in their lifetime.[4][7] They occur most frequently between the ages of 16 and 35 years.[7] Recurrences are common.[7] Urinary tract infections have been described since ancient times with the first documented description in the Ebers Papyrus dated to c. 1550 BC.[20]
2:28CC
Video summary (script)
Signs and symptoms
Urine may contain pus (a condition known as pyuria) as seen from a person with sepsis due to a urinary tract infection.

Lower urinary tract infection is also referred to as a bladder infection. The most common symptoms are burning with urination and having to urinate frequently (or an urge to urinate) in the absence of vaginal discharge and significant pain.[4] These symptoms may vary from mild to severe[10] and in healthy women last an average of six days.[19] Some pain above the pubic bone or in the lower back may be present. People experiencing an upper urinary tract infection, or pyelonephritis, may experience flank pain, fever, or nausea and vomiting in addition to the classic symptoms of a lower urinary tract infection.[10] Rarely, the urine may appear bloody[7] or contain visible pus in the urine.[21]

UTIs have been associated with onset or worsening of delirium, dementia, and neuropsychiatric disorders such as depression and psychosis.[22][23][24] The reasons for this are unknown, but may involve a UTI-mediated systemic inflammatory response which affects the brain.[22][23][25][26] Cytokines such as interleukin-6 produced as part of the inflammatory response may produce neuroinflammation, in turn affecting dopaminergic and/or glutamatergic neurotransmission as well as brain glucose metabolism.[22][23][25][26]
Children

In young children, the only symptom of a urinary tract infection (UTI) may be a fever.[27] Because of the lack of more obvious symptoms, when females under the age of two or uncircumcised males less than a year exhibit a fever, a culture of the urine is recommended by many medical associations.[27] Infants may feed poorly, vomit, sleep more, or show signs of jaundice.[27] In older children, new onset urinary incontinence (loss of bladder control) may occur.[27] About 1 in 400 infants of 1 to 3 months of age with a UTI also have bacterial meningitis.[28]
Elderly