Lesson on the RANKL / RANK / OPG Signaling Pathway: Purpose and Mechanism. The RANKL-RANK-OPG Signaling pathway is an important pathway in bone remodelling and is important in various osteopathies such as osteoporosis. Osteoblasts are bone forming cells, which express and release the protein RANK ligand (RANKL) and osteoprotegerin (OPG). RANK ligand binds to the RANK receptor, which is located on bone absorbing cells known as osteoclasts. RANK ligand binding to RANK receptor leads to the differentiation and activation of osteoclasts. Activation of osteoclasts enables them to reabsorb bone to ensure bone remodelling occurs.

Hey everyone. In this lesson you will learn about the RANKL-RANK-OPG Signaling Pathway, its purpose in bone remodelling, and the various downstream signaling targets of the pathway, including PI3K-AKT signaling, JNK signaling, and NFKB signaling.

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JJ

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**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.

Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.

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