Lesson on One Carbon Metabolism, the role of tetrahydrofolate and the folate cycle. Tetrahydrofolate (THF) is derivative of folic acid (Vitamin B9), which is acquired from dietary sources. Tetrahydrofolate (THF) in various forms (N5,N10-methylene THF etc.) acts as a carbon donor, allowing cells to produce nucleic acids, amino acids and methionine and s-adenosyl methionine in the activated methyl cycle.

***Re-uploaded to correct mistake***

Hey guys! In this lesson you will learn about one carbon metabolism, tetrahydrofolate and its role in producing various cellular products needed for purine and pyrimidine synthesis. You will also learn which dietary sources contain folic acid (folate), how folate is processed to tetrahydrofolate, and you will also learn the enzymes of the pathway. The anti-cancer medications known as methotrexate and 5-fluorouracil and their enzyme targets will also be discussed. Finally, you will also learn how the one carbon metabolism pathway is connected with the activated methyl cycle and methionine metabolism.

Hope you all find it helpful.
JJ

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Check out some of my other lessons.

Medical Terminology - The Basics - Lesson 1:
https://www.youtube.com/watch?v=04Wh2E9oNug

Fatty Acid Synthesis Pathway:
https://www.youtube.com/watch?v=WuQS_LpNMzo

Wnt/B Catenin Signaling Pathway:
https://www.youtube.com/watch?v=NGVP4J9jpgs

Upper vs. Lower Motor Neuron Lesions:
https://www.youtube.com/watch?v=itNd74V53ng

Lesson on the Purine Synthesis and Salvage Pathway:
https://www.youtube.com/watch?v=e2KFVvI8Akk

Gastrulation | Formation of Germ Layers:
https://www.youtube.com/watch?v=d6Kkn0SECJ4

Introductory lesson on Autophagy (Macroautophagy):
https://www.youtube.com/watch?v=UmSVKzHc5yA

Infectious Disease Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW0Bkc6c66uDACkzotaK26b

Dermatology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW3dgORRNmk_MZvnWpZx_lW

Pharmacology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwWPWcV9lZTh-Qxv0gYakQXR

Hematology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW8Ajo1dmxdj4EYEKcbtGju

Rheumatology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwWDvuhasXsuTFXJp05wwUle

Endocrinology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwUuRSzhploohnaWVvbVZ7ZP

Nephrology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwXRSwrFQK5WwWZLk1Las8v8

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**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.

Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.

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*Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.*

I am always looking for ways to improve my lessons! Please don't hesitate to leave me feedback and comments - all of your feedback is greatly appreciated! :) And please don't hesitate to send me any messages if you need any help - I will try my best to be here to help you guys :)

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JJ