Lesson on macroautophagy and regulation by fasting and starvation, with an additional detailed overview of how macroautophagy is inhibited during feeding and the fed state. Macroautophagy is a nutrient responsive process and is inhibited during feeding and the fed state when nutrient and energy levels are high. During short-term fasting, macroautophagy becomes activated by AMPK, and inhibition of mTOR leads to further activation of macroautophagy and activation of transcription factor EB (TFEB), which is the master regulator of lysosomal biogenesis and autophagy.

Hey everyone. Here is another lesson on macroautophagy. This is a continuation of the "Autophagy: Introduction to Macroautophagy" lesson, and further elaborates on how macroautophagy is regulated, in particular by nutrient status of the cell including the fed state, and fasting and starvation. We also briefly introduce the idea of a chronological differentiated activation during fasting of different proteolytic systems with acute activation of the ubiquitin proteasome system, macroautophagy activation within 4 hours of fasting and chaperone-mediated autophagy activation within 12 hours of fasting. We will discuss this topic further in a future lesson.

Before watching this lesson, please check out this introductory lesson on Macroautophagy:
https://www.youtube.com/watch?v=UmSVKzHc5yA

For more information on Chaperone-mediated autophagy (CMA), please check out this lesson:
https://www.youtube.com/watch?v=M5kr1W8sWV0

For an in-depth review of the mTOR signaling pathway, please check out this lesson:
https://www.youtube.com/watch?v=-2pXbSpDPQE

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Check out some of my other lessons.

Medical Terminology - The Basics - Lesson 1:
https://www.youtube.com/watch?v=04Wh2E9oNug

Fatty Acid Synthesis Pathway:
https://www.youtube.com/watch?v=WuQS_LpNMzo

Wnt/B Catenin Signaling Pathway:
https://www.youtube.com/watch?v=NGVP4J9jpgs

Upper vs. Lower Motor Neuron Lesions:
https://www.youtube.com/watch?v=itNd74V53ng

Lesson on the Purine Synthesis and Salvage Pathway:
https://www.youtube.com/watch?v=e2KFVvI8Akk

Gastrulation | Formation of Germ Layers:
https://www.youtube.com/watch?v=d6Kkn0SECJ4

Introductory lesson on Autophagy (Macroautophagy):
https://www.youtube.com/watch?v=UmSVKzHc5yA

Infectious Disease Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW0Bkc6c66uDACkzotaK26b

Dermatology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW3dgORRNmk_MZvnWpZx_lW

Pharmacology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwWPWcV9lZTh-Qxv0gYakQXR

Hematology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW8Ajo1dmxdj4EYEKcbtGju

Rheumatology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwWDvuhasXsuTFXJp05wwUle

Endocrinology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwUuRSzhploohnaWVvbVZ7ZP

Nephrology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwXRSwrFQK5WwWZLk1Las8v8

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**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.

Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.

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*Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.*