Lesson on chaperone-mediated autophagy (CMA). CMA is a selective degradation process involving the use of protein chaperones, which target and deliver KFERQ-containing protein cargo to the lysosome for degradation. The chaperone complex in CMA consists of a variety of proteins including Hsc70 and Hsp90, which have important functions for CMA. CMA function requires not only proper chaperone functioning, but also lysosomal functioning. Decreased lysosomal functioning due to decreased lysosomal acidification, results in suppression of CMA. When the CMA chaperone complex delivers the protein cargo to the lysosome, the protein cargo is bound, unfolded and then translocated through a lysosomal membrane receptor known as LAMP2A. The protein cargo is then degraded within the lysosome via proteases known as cathepsins. LAMP2A is indispensable for CMA functioning and a deficiency of LAMP2A can lead to a condition known as Danon disease.

Hey everyone. Here is another lesson on autophagy - this time it is on chaperone-mediated autophagy (CMA). In this lesson, you will learn the differences between CMA and macroautophagy, when CMA is active and inactive, and how CMA “selects” its protein cargo through the KFERQ consensus sequence and what the KFERQ sequence is. You will also learn about the roles and purposes of each of the proteins in the chaperone complex, and you will learn the importance and role of various lysosomal proteins in CMA functioning. Finally, you will briefly learn about the genetic condition known as Danon disease, which is due to a deficiency in LAMP2A receptor.

I hope you find this video helpful. If you did, please like and subscribe for more videos like this :)

JJ

*Subscribe for more free medical lessons* https://www.youtube.com/channel/UCFPvnkCZbHfBvV8ApBBE0vA?sub_confirmation=1

-------------------------------------------------------------------------------------------------------------
For books and more information on these topics
https://www.amazon.com/shop/jjmedicine

Support future lessons (and get other cool stuff) https://www.patreon.com/jjmedicine

Follow me on Twitter! https://twitter.com/JJ_Medicine

Come join me on Facebook! https://www.facebook.com/JJ-Medicine-100642648161192/

Start your own website with BlueHost https://www.bluehost.com/track/jjmedicine/

Check out the best tool to help grow your YouTube channel (it’s helped me!)
https://www.tubebuddy.com/jjmedicine

-------------------------------------------------------------------------------------------------------------

Check out some of my other lessons.

Medical Terminology - The Basics - Lesson 1:
https://www.youtube.com/watch?v=04Wh2E9oNug

Fatty Acid Synthesis Pathway:
https://www.youtube.com/watch?v=WuQS_LpNMzo

Wnt/B Catenin Signaling Pathway:
https://www.youtube.com/watch?v=NGVP4J9jpgs

Upper vs. Lower Motor Neuron Lesions:
https://www.youtube.com/watch?v=itNd74V53ng

Lesson on the Purine Synthesis and Salvage Pathway:
https://www.youtube.com/watch?v=e2KFVvI8Akk

Gastrulation | Formation of Germ Layers:
https://www.youtube.com/watch?v=d6Kkn0SECJ4

Introductory lesson on Autophagy (Macroautophagy):
https://www.youtube.com/watch?v=UmSVKzHc5yA

Infectious Disease Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW0Bkc6c66uDACkzotaK26b

Dermatology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW3dgORRNmk_MZvnWpZx_lW

Pharmacology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwWPWcV9lZTh-Qxv0gYakQXR

Hematology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW8Ajo1dmxdj4EYEKcbtGju

Rheumatology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwWDvuhasXsuTFXJp05wwUle

Endocrinology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwUuRSzhploohnaWVvbVZ7ZP

Nephrology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwXRSwrFQK5WwWZLk1Las8v8

----------------------------------------------------------------------------------------------------

**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.

Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.

----------------------------------------------------------------------------------------------------

*Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.*