Lesson on the Cori cycle, introducing the importance and purpose of the Cori cycle and discussing how the Cori cycle can recycle lactic acid, produced from anaerobic metabolism in skeletal muscle, in the liver to form glucose through gluconeogenesis. Intensive exercise and other hypoxic conditions induce anaerobic metabolism in muscle cells, which leads to the production of lactic acid from pyruvate via the enzyme lactate dehydrogenase (LDH). If this lactic acid is left in the muscle cell, the pH of the muscle cell can decrease and cause detrimental effects to the muscle. Therefore, the lactic acid is transported out of the muscle cell through specific transporters located in the muscle cell membrane. The hydrogen ions from the lactic acid are then buffered by the blood and/or removed from the blood in the form of carbon dioxide. The remaining lactate is transported into the liver, where it can be used as a precursor for gluconeogenesis.

Hey everyone! Here is a lesson on the Cori cycle and lactic acid metabolism. In this lesson, you will learn the differences between aerobic and anaerobic metabolism in skeletal muscle, and how lactic acid is produced. You will also learn how that lactic acid is transported out of the cell and into the blood, and how the blood buffers and removes excessive hydrogen ions (protons) produced from lactic acid hydrolysis. This video then discusses how the lactate is transported into the liver hepatocyte, and how the lactate is used as a precursor for gluconeogenesis.

I hope you found this video helpful! If you did find this video helpful, please like this video and consider subscribing to my channel to show your support for my medical education videos :)

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Check out some of my other lessons.

Medical Terminology - The Basics - Lesson 1:
https://www.youtube.com/watch?v=04Wh2E9oNug

Medical Terminology - Anatomical Terms:
https://www.youtube.com/watch?v=KkXiE3NEJxw

Fatty Acid Synthesis Pathway:
https://www.youtube.com/watch?v=WuQS_LpNMzo

Wnt/B Catenin Signaling Pathway:
https://www.youtube.com/watch?v=NGVP4J9jpgs

Upper vs. Lower Motor Neuron Lesions:
https://www.youtube.com/watch?v=itNd74V53ng

Lesson on the Purine Synthesis and Salvage Pathway:
https://www.youtube.com/watch?v=e2KFVvI8Akk

Gastrulation | Formation of Germ Layers:
https://www.youtube.com/watch?v=d6Kkn0SECJ4

Introductory lesson on Autophagy (Macroautophagy):
https://www.youtube.com/watch?v=UmSVKzHc5yA
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I am always looking for ways to improve my lessons! Please don't hesitate to leave me feedback and comments - all of your feedback is greatly appreciated! :) And please don't hesitate to send me any messages if you need any help - I will try my best to be here to help you guys :)

Thanks for watching! If you found this video helpful, please like and subscribe! JJ
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DISCLAIMER: This video is for educational purposes only and information in this lesson SHOULD NOT be used for medical purposes alone. Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.