“Colon Cancer That Runs in Families” (Familial Adenomatous Polyposis), APC Gene, Symptoms, Diagnosis, Treatment

Familial Adenomatous Polyposis is an autosomal dominant inherited condition involving significantly increased risk of colorectal or colon cancer. Familial Adenomatous Polyposis can lead to colon cancer very early on in life, roughly by the age of 40 in most individuals. Familial Adenomatous Polyposis is caused by a mutation in the APC gene, which itself is involved in a biochemical pathway known as the Wnt-B catenin signaling pathway. Familial Adenomatous Polyposis often has no symptoms until the onset of colorectal cancer. In this lesson, we discuss the pathophysiology behind with Familial Adenomatous Polyposis occurs, how it is diagnosed and how it is treated.

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JJ

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