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In this video I describe the diathesis-stress model. This model suggests that development of mental illness can be explained by two main factors - a genetic predisposition (diathesis) and environment (stress). Individuals vary for both of these factors and these variations can help us to understand why some people develop a mental illness and others don't. Next I discuss how this model is an oversimplification because it ignores the potential interaction between genes and environment and how experiences may alter gene expression. This can be seen in a study by Caspi et al (2003) which found a relationship between versions of a serotonin transporter gene and depression, but only when accompanied by stressful life events.

Disclaimer: This channel is for educational purposes only and is not intended as medical advice for the diagnosis or treatment of psychological disorders.

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Caspi et al (2003) - Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene
http://sci-hub.tw/10.1126/science.1083968