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In this video I explain the concept of long-term potentiation, which refers to the strengthening of neural connections due to repeated synchronous firing. Repeated firing leads to changes in chemical signaling between the two neurons, influencing neurotransmitter and receptor activity. Next I introduce an example of this with the possible role of the N-methyl-D-aspartate receptor (for the neurotransmitter glutamate) in memory and learning. This has been demonstrated in mice given NMDA antagonists which then impaired their performance on the Morris water maze.
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Morris Water Maze Demonstration:
https://www.youtube.com/watch?v=LrCzSIbvSN4