?What role do chaperone proteins play in Chaperone-Mediated Autophagy (CMA)

Chaperone proteins assist in the recognition and targeting of specific proteins destined for degradation via CMA. They recognize the KFERQ-like motif in substrate proteins, facilitating their transport across the lysosomal membrane for degradation.

?How does dysfunction in Chaperone-Mediated Autophagy contribute to disease pathology

Dysfunction in CMA can lead to the accumulation of damaged or misfolded proteins within cells, contributing to various neurodegenerative diseases, such as Alzheimer's and Parkinson's. Additionally, impaired CMA has been implicated in cancer progression, as it affects cellular quality control mechanisms and promotes tumorigenesis.

Chaperone Mediated Autophagy Regulation

Track :

Medical

Lessons no : 5

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Lessons | 5

00:14:27

Macroautophagy Transcriptional Regulation Lesson 2

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Chaperone Mediated Autophagy course, In this course we will delve into the intricacies of CMA, exploring its molecular mechanisms, regulatory pathways, and clinical relevance. Through lectures and discussions, students will gain insights into how chaperone proteins facilitate the degradation of damaged or aggregated proteins, contributing to overall cell health and disease prevention.